Ellinogermaniki Agogi (EA) is one of the most innovative schools in Europe with more than 60 years of operation. It has 2500 students (ages 5 to 18 years old) and 250 teachers in different disciplines. EA has a very strong vision-generated interest and rich research and development activity in the fields of Inquiry Based Science Education (IBSE), Project Based Learning (PBL), and STEM education in combination with digital, online based learning environments and tools. Established in 1995, the Research and Development Department of EA is guiding the introduction of innovation in the school setting. The R&D Department acts as an interface between the pedagogical research, the technological innovation and the school community. It focuses on the design, implementation and support of pedagogical and technological innovation in educational practice, both through internal research as well as through collaborations with numerous educational, research and commercial institutions in Europe and the world. EA is an institutional member of EDEN (European Distance Education Network), of STEDE (Science Teacher Education Development in Europe), of ECSITE (European Network of Science Centres and Museums) network and a partner school of the German Excellence Network of STEM Schools “MINT-EC” (https://www.mint-ec.de/). The school operates, since 2001, a Center for Teachers Training, Certified from the Ministry of Education, to deliver course to teachers from East Attica (with physical presence) and from all over Greece (through distance learning).